Two Seriously Injured in Multi-Vehicle Collision on I-25 in Denver

DENVER, CO 10/21/2025. A serious traffic incident resulting in two injuries was reported on October 21, 2025, at approximately 3:05 PM MT, near I-25 Northbound and E. Hampden Ave. The incident took place roughly 0.8 miles northwest of the major intersection. Involving a passenger car and an SUV, the crash occurred under dark but lighted conditions and primarily involved a series of harmful events including front to rear, front to side impact, and an overturning/rollover sequence. The car was reportedly changing lanes recklessly when the collision occurred. Fortunately, there were no fatalities reported. This incident adds to the 445 traffic-related incidents reported in the Hampden South neighborhood over the past year.

The O’Sullivan Law Firm is dedicated to the safety of all Coloradans. If you, or someone you know, has been injured or affected by the negligence of others, please contact the O’Sullivan Law Firm for a free consultation. Call us at 303-388-5304 or reach out to us online.

_{Data sources include City of Denver Open Data Catalog used under the license terms of CC BY 3.0}